The smart Trick of rheumatoid arthritis meaning in hindi That Nobody is Discussing

In the world, more and more and more people are suffering from the failure of their immune systems to distinguish between healthy cells and invading microscopic organisms. The immune system is being attacked with the immune defenses to diseases that were once there to defend them.




Major international research efforts are underway to stop this trend. A London-based organization called the Francis Crick Institute, has two world-renowned experts. James Lee & Carola Vinuesa set up separate research teams to figure out the exact causes of autoimmune disease.


Lee stated that cases of autoimmune disease are on the rise since around 40 years ago in the West. However, some of these cases are now occurring in countries where they have never had such illnesses before.


The Middle East and East Asia are experiencing the greatest growth in cases of inflammatory bowel diseases. They'd never seen the disease before.


Autoimmune diseases can vary from type 1 diabetes, to multiple Sclerosis chronic fatigue syndrome, Rheumatoid Arthritis. In all cases, the immune system focuses on healthy tissue and not infective agents.


In the UK alone, more than 4 million people have been diagnosed with the condition, with some sufferers suffering from more than one. According to estimates from international sources that the number of sufferers of autoimmune diseases is rising by anywhere from 3% to nine percent per year. Many scientists believe that environmental factors play the major part in this increase.


Lee, who was previously in Cambridge University, says that the human genetics haven't changed in the last decade. There's something else that's causing our predisposition to autoimmune disease.


Vinuesa was in favor of the idea, having previously worked in the Australian National University. She highlighted changes in the diet happening as more nations adopted western-style eating habits and consumers bought more fast food.


Vinuesa said that fast food meals contain a few essential ingredients, like fiber. The evidence suggests that this can affect a person's microbiome which is the accumulation of microorganisms in our gut. Microorganisms play a important role in controlling a variety of bodily functions.


Microbiomes are the microbiome that is altered. This leads to autoimmune diseases. There are more than 100 types.


Both scientists said that individuals are susceptible to getting these diseases. They include celiac and Lupus, which trigger swelling and inflammation, and cause damage to various organs including the heart.


Vinuesa claims that anyone who doesn't suffer from a genetic susceptibility to develop an autoimmune disorder regardless of how many Big Macs they eat. "There isn't much that we can do to stop the spread of fast food franchises. Instead, we're trying to understand how autoimmune diseases occur and the genetic factors that make certain people more susceptible than others. This is how we want to solve the problem."


Because of the advancement of technology, scientists are now in a position to detect small differences in people's DNA. This allows us to find the common genetic traits in people with autoimmune diseases.


Up until recently we didn't have the technology to do Read More this, however, we're in a position to analyze DNA on a massive scale and that has changed everything, said Lee. We knew only about half a dozen variants of DNA that could trigger inflammation in the bowel when I started my research. We now have over 250.


Such work lies at the heart of Lee and Vinuesa's work, which aim to find out how these various genetic pathways work and decipher the many different types of diseases doctors are looking at. Vinuesa explained that autoimmune diseases such as Lupus, for example are present in various forms and could have different genetic causes. If you're trying to determine the most effective treatment for your condition it can become a problem.


There are many new therapies being developed and we don't know who we should give these to. Because we don’t know the exact cause of their illness there are numerous options. That is the goal of Click here autoimmune research. To provide the best treatment, we must learn how to categorize patients.


Lee stated that the rising incidence of autoimmune diseases across the globe means that new treatments and medications are required now more than ever before. There are no current treatments for autoimmune diseases, which often occur in young peoplewho are trying to land their first job, graduate from school, and raise their families.


This means that increasing numbers of people will need to undergo surgery or regular injections. This could be extremely difficult for patients and place stress on health care systems. It is crucial that we find new treatment options that are more efficient and effective.


Rheumatoid Arthritis is an autoimmune disorder. This means the immune system attacks healthy tissue. It's unclear what causes this.


Your immune system normally makes antibodies that fight against viruses and bacteria, assisting to fight infections.


If you have rheumatoid arthritis, your immune system mistakenly sends antibodies to the lining of your joints, where they attack the tissue surrounding the joint.


This causes the thin cells-like layer of your joints (synovium), to get inflamed and sore this releases chemicals that cause harm around the joint.


bones

Cartilage is the connective tissue between bones which is composed of cartilage.

Tendons are the connective tissue that connects bone and muscles.

Ligaments form the connective tissue between bone and cartilage.

If rheumatoid isn't treated it will cause the joint lose its shape. It can eventually cause the total destruction of the joint.


Many theories on the reason why the immune system attacks joints have been proposed, such as an infection acting as a trigger, but none of them have been proved.

Possible risk factors

There are many things which can increase your risk of developing rheumatoid, for example:


It is possible to inherit it through your genes. While there are indications that rheumatoid arthritis could be passed down through the family, the chances of getting it are very low since genes only play a very tiny role in the disease.

Hormone-Rheumatoid Ailment is more frequent for women than men. It could be due to estrogenic effects, but this isn't confirmed.

Smoking - Some evidence suggests that smokers are at a higher chance of developing rheumatoid arthritis.