The smart Trick of rheumatoid arthritis diagnosis That No One is Discussing

Many people around the globe suffer with an immune system that is unable to discern between healthy cells invader bacteria, and diseases. They are being attacked by the immune defenses to diseases which were previously there to protect them.




Major international research efforts are underway to fight this trend - including an initiative at London's Francis Crick Institute, where two world experts, James Lee and Carola Vinuesa, have set up separate research groups to help pinpoint the precise nature of the autoimmune disorder, as these conditions are known.


The number of cases of autoimmune diseases began to increase about 40 years ago in the West, Lee told the Observer. However, some of these cases are now occurring in countries that have not had such illnesses before.


The Middle East, East Asia and Africa have had the highest increase in inflammatory bowel disorder cases over the last few years. They had not seen the disease prior to.


Autoimmune diseases vary from type 1 diabetes to multiple MS as well as chronic fatigue syndrome and Rheumatoid Arthritis. In each case the immune system is activated and its wires crossed, and it turns to healthy tissues instead of the infectious agents.


There are at most 4 million people suffering from autoimmune diseases in the UK, and some suffer from multiple. It is estimated that autoimmune conditions are increasing by between 3to 9 percent each year across the globe. The majority of scientists believe that the environment plays a significant part in this increase.


Lee who was formerly in Cambridge University, says that human genetics hasn’t changed over the past decade. There's a possibility that something is happening in the world outside that is increasing our susceptibility to autoimmune disease.


Vinuesa who was a former student at the Australian National University, supported this concept. She mentioned that there were shifts in diets as more people ate western-style meals and increased consumption of fast food.


Fast-food diets lack certain essential ingredients, like fibre. Evidence suggests that this can affect a person's microbiome - the group of micro-organisms we have in our digestive tract and that are essential in controlling different bodily functions, Vinuesa said.


These changes in the microbiomes could trigger autoimmune conditions. More than 100 different types of autoimmune diseases have been discovered.


The two scientists also stressed that everyone is susceptible to developing these illnesses including celiac Lupus, and various other illnesses, such as celiac, that cause swelling and inflammation and can cause serious damage to the organs of various.


Vinuesa claims that anyone who does not have a particular genetic susceptibility to develop an autoimmune disease regardless of the amount of Big Macs they consume. We can't change the widespread expansion of fast-food chains across the globe. Instead, we're trying to figure out how autoimmune conditions can be caused and the genetic factors that make certain people more susceptible than others. We're determined to tackle this issue at the most fundamental levels.


Due to the advances in technology, researchers are able to find tiny differences between people's DNA. In this way, it is possible to determine the common genetic patterns that are common to those suffering from an autoimmune disease.


Lee explained that the capability to sequence huge amounts of DNA has revolutionized the way we do everything. We didn't have this technology until recently. My research revealed that there are about six DNA variants that were involved in the trigger of inflammatory bowel disease. There are now more than 250.


Lee and Vinuesa concentrate their efforts on this type of research. They are keen to find out more about genetic pathways and find the causes of the various diseases they are studying. Vinuesa explained that there may be multiple versions of certain autoimmune disorders, like Lupus. This can make it challenging to identify the appropriate treatment.


There are numerous new therapies being developed, however, we aren't sure which patients Check out we should give them. We don't even know what type of disease the patient is suffering from. That is the goal of research on autoimmune disease. So that we can provide the best therapy it is essential to be able group and stratify patients.


Lee added that the increasing cases of autoimmune illnesses across the globe meant that new therapies and medicines were much more urgently needed than before. There are currently no cures for autoimmune illnesses that usually manifest at a young age - as they attempt to finish their education, find their first job, and start families, Lee said.


This means that more and more of patients will need undergo surgery or receive regular injections. This can be very difficult for patients and an enormous strain on healthcare services. Hence the urgent need to develop new, effective treatment options.


Rheumatoid arthritis is an immuno-mediated disease. This is a mystery.


The antibodies that your immune system produces to fight viruses and bacteria are essential to fight off infection.


If you suffer from Rheumatoid arthritis, your immune systems mistakenly transmits antibodies to your joints in the lining, which attack the surrounding tissues.


The delicate layer of cells (synovium) that covers your joints, is prone to inflammation and swollen.


bones

Cartilage - The connective tissue that connects cartilage Read More and bones

The tendons are the tissue that connects bone to muscle

Ligaments - The tissue that connects cartilage and bone

If the problem isn't addressed, it will gradually cause the loss of alignment and form. Eventually, it can destroy the joint completely.


There are many theories about why the immune response targets joints. For instance an infection could be the trigger. But none of these theories is proven.

Possible risk factors

There are a variety of factors that may increase your risk of developing rheumatoid arthritis including:


You could inherit it from your genes. Although there are some indicators that suggest that rheumatoidarthritis could be passed through families, the chances of getting it are very low since genes play a small role in the condition.

Hormones - Rheumatoid Arthritis is more prevalent in women than in males. This could result from the effect of Oestrogen. But this connection is not yet established.

Smoking is a risk factor for rheumatoid artifiid. There is evidence to support this.